Step 1: Ionization to form 1 H Step 2: 1-2 Hydride shift Step 3: Attack of the brm the more stable3° Nucleophile The most significant factor in determining whether a given substitution reaction will follow an S,I or an S, 2 mechanism is the nature of the reactant the more stable the potential carbocation, the more likely an s,I mechanism becomes. Therefore, primary alkyl halides will generally follow pure pathways, tertiary alky l halides will generally follow S,1 pathways, and secondary alky l halides may follow either, depending on the exact nature of the compound Br一 Reactivity in S2 Reaction 教学手段与方法:课堂讲授,幻灯投影谱图。 思考题、讨论题、作业:第254面. Additional problems;612-6.30 参考资料(含参考书、文献等) 1. Solomons, Organic Chemistry, fifth adition 2. Oxford: Organic Chemistry 3.北京大学,有机化学 4.南京大学,有机化学,(上,下) 5.邢其毅,有机化学,(上,下) 注:1、每项页面大小可自行添减;2一次课为一个教案;3、“重点"、“难点”、“教学手段The most significant factor in determining whether a given substitution reaction will follow an SN1 or an SN2 mechanism is the nature of the reactant; the more stable the potential carbocation, the more likely an SN1 mechanism becomes. Therefore, primary alkyl halides will generally follow "pure" SN2 pathways, tertiary alkyl halides will generally follow SN1 pathways, and secondary alkyl halides may follow either, depending on the exact nature of the compound. 教学手段与方法：课堂讲授，幻灯投影谱图。 思考题、讨论题、作业：第 254 面. Additional Problems; 6.12-6.30) 参考资料（含参考书、文献等）： 1. Solomons, Organic Chemistry, fifth adition 2. Oxford; Organic Chemistry 3. 北京大学， 有机化学 4．南京大学， 有机化学，（上，下） 5．邢其毅，有机化学， （上，下） 注：1、每项页面大小可自行添减；2 一次课为一个教案；3、“重点”、“难点”、“教学手段