BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 4. regulated release a. devices with externally-applied trigger to turn release on/off electrical (SLIDE) transdermal - Alza MacrofiuxB patch Osmotic pump·Aza Duros imilar Titanium microprojections t Osmotic engine Adhesive backing f Delivery orifice Titanium rod cas Osmotic engine: (one form Osmotic pump- Alza Duros implant Favorable Asmix Drug reservoir Titanium rod casing rug out other end b. benefit of complex control C. generally more bulky devices and require implantation Device types 1-4 generally pre-programmed *DISCUSSION OF #5 NEXT DAY IN COMPLEX RELEASE PROFILES Lecture- Controlled release devices 5 of 14BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 4. regulated release a. devices with externally-applied trigger to turn release on/off i. electrical5 ii. mechanical (SLIDE) transdermal - Alza Macroflux® patch Osmotic pump - Alza Duros¨ implant Semipermeable membrane QuickTime™ and a Graphics decompressor are needed to see this picture. Osmotic engine piston Drug reservoir Delivery orifice Titanium rod casing Titanium microprojections Adhesive backing Drug matrix Osmotic engine: (one form) Osmotic pump - Alza Duros¨ implant needed to see this picture. Semipermeable membrane Osmotic engine piston Drug reservoir Delivery orifice b. benefit of complex control Favorable ∆Smix Titanium rod casing Water driven into ; swelling drives piston to push ÔengineÕ drug out other end c. generally more bulky devices and require implantation • Device types 1-4 generally ‘pre-programmed’ • *DISCUSSION OF #5 NEXT DAY IN COMPLEX RELEASE PROFILES Lecture 5 – Controlled Release Devices 5 of 14