012-3-11 Treatment of utis The principles of UTIs treatment m All symptomatic UTIs should be treated and inflammatory secretions from the urine s The purpose of early treatment of cystitis is to reduce the risk of progression to pyelonephritis nosis. but also to the treatment(direct m In patients with pyelonephritis, early treatment is reduce the duration of symptoms n eliminate microorganisms from the renal parenchyma therapy reduce the risk of dissemination to the blood (3-5days), while upper tract infection required longer The principles of UTIs treatment(cont Antibiotics used to treat cystitis a If common antibiotics are ineffective. the 80/400 mg qTh for 3 days following microorganisms should be considered mg qsh for 5-7 days mycoplasm Antibiotics used to treat pyelonephrits Antibiotics used to treat pyelonephrits OUTE OF AND ANTIMICROBIAL AL Amoxicillin/clavulanic acid 500 mg(amoxicillin Only step-down therapy I Eyal Cefuroxime axetil Only step-down therapy Cefpodoxime proxetil Only step-down therapy Cefixime Only step-down therap s me Ceftibuten Only step-down therap Clprotloacin 100 mg q12h Levofloxacin 250 mg/day2012-3-11 8 Treatment of UTIs „ All symptomatic UTIs should be treated. „ The purpose of early treatment of cystitis is to reduce the risk of progression to pyelonephritis. „ In patients with pyelonephritis, early treatment is important to: … reduce the duration of symptoms, … eliminate microorganisms from the renal parenchyma, … reduce the risk of dissemination to the blood The principles of UTIs treatment „ Drink more water to promote the elimination of bacteria and inflammatory secretions from the urine. „ Factors predisposing to infection should be identified and corrected „ Urine culture is important not only to the diagnosis, but also to the treatment (direct therapy ) as well. „ Relilef of clinical symptoms does not always indicate bacteriologic cure „ In general, uncomplicated infections confined to the lower urinary tract respond to short courses of therapy (3-5days), while upper tract infection required longer treatment (14 dalys). The principles of UTIs treatment(cont.) „ If common antibiotics are ineffective, the following microorganisms should be considered: … Resistant bacteria Resistant bacteria … Unusual microorganisms, including anaerobic bacteria, mycobacterium tuberculosis, L bacterium, mycoplasma Antibiotics used to treat cystitis Antibiotics used to treat pyelonephrits Antibiotics used to treat pyelonephrits