GLUCOCORTICOID- METABOLISM OH OH Hydrocortisone Oxidation HO OH OH Cortisone o Oxidation/reduction Reduction OH COOH HO H OH HO -OH OH HO HO H 3-keto-A4 and 20-keto reduced Acid metabolitesGLUCOCORTICOID - METABOLISM O HO O OH OH O O O OH OH Cortisone Hydrocortisone Oxidation Reduction OH H OH HO HO HO H 3-keto-D4 and 20-keto reduced COOH OH OH H HO HO H Oxidation/reduction Acid metabolites