T-Dependent mechanism Macrophage presents part of Ag and own class II MHC to T-helper cell(signal #1) Also makes ILl 6 signal #2) IL1 6 stimulates t cell clone to divide and make il2 4-6 ILl also stimulates hypothalamus to raise body temperature, enhancing T cell action BIOL 533 Lecture 7BIOL 533 6 Lecture 7 T-Dependent Mechanism • Macrophage presents part of Ag and own class II MHC to T-helper cell (signal #1) • Also makes IL1 6 (signal #2) – IL1 6 stimulates T cell clone to divide and make IL2 4-6 – IL1 also stimulates hypothalamus to raise body temperature, enhancing T cell action