HUASHAN HOSPITA 莘山院 MECHANISMS OF ESSENTIAL HYPERTENSION 3) >Insulin Resistance/ hyperinsulinemia increase arterial pressure. mechanism unclear o Hyperinsulinemia produces renal sodium retention and increases sympathetic activity o Vasular smooth-muscle hypertrophy secondary to the mitogenic action of insulin O Insulin modifies ion transport across the cell membrance Insulin Resistance/ hyperinsulinemia— increase arterial pressure…mechanism unclear  Hyperinsulinemia produces renal sodium retention and increases sympathetic activity  Vasular smooth-muscle hypertrophy secondary to the mitogenic action of insulin  Insulin modifies ion transport across the cell membrance. MECHANISMS OF ESSENTIAL HYPERTENSION (3)