Nephropathia s associated with aNCA (ANCA -Anti-Neutrophil Cytoplasmic Antibody Renal Involvement (common in Vasculitis) PAN (Polyarteritis Nodosa) Wegener Granulomatous Arteries outside glomerulus Arterieswithin the Glomerulus affected atfected Lesions Focal, Segmental Distribution wth Fibrinoid Necrosis, Crescent Formation Presence of anca Strong correlation between Presence of ANCA, Glomerular Involvement in Vasculitis(but precise mechanism not understood Treatment Early Phase Rapid Progressive GN Glucocorticoids Pulse Methylprednisolone Prednisolone, Cyclopho sphamide Plasmapheresis (value not proven Renal Vasculitis ANCA Test Positivity (%) P-ANCA C-ANCA PAN 10-20 10-20 Microsco pic Polyangitis 5080 10-20 Wegener Granulomatosis 10-20 8090 Necrotizing, Cresce ntic GN 5080 1020