©上特 - 国人线 Metered dose inhalers Metered dose inhalers ·Aerosol Propellant-driven metered dose inhaler Pressurized metered dose inhaler .Pressurized aerosol 圈卢生Definition and Classification 圈上生 Pharmaceutical aerosol Advantages of the aerosol ·Absorb quickly It may be defined as an aerosol product Minimum contamination containing therapeutically active ingredients ·Improve stability dissolved,suspended,or emulsified in a Convenient to use propellant or a mixture of solvent and propellant Avoid first pass metabolism in GIT and liver and intended for inhale or topical administration Accurate dose or administration into body cavities. Suitable for local or systemic agents Non-invasive;Patient friendly 国坠生一 圈生 Disadvantages of the aerosol Metered dose inhaler ·Expensive ·Propellants Product concentrate ·Cooling effect .Container Patient coordination ·Valve 33 Metered dose inhalers Shanghai Jiao Tong University Metered dose inhalers • Aerosol • Propellant-driven metered dose inhaler • Pressurized metered dose inhaler • Pressurized aerosol Shanghai Jiao Tong University Definition and Classification Pharmaceutical aerosol • It may be defined as an aerosol product containing therapeutically active ingredients dissolved, suspended, or emulsified in a propellant or a mixture of solvent and propellant and intended for inhale or topical administration or administration into body cavities. Shanghai Jiao Tong University Advantages of the aerosol • Absorb quickly • Minimum contamination • Improve stability • Convenient to use • Avoid first pass metabolism in GIT and liver • Accurate dose • Suitable for local or systemic agents • Non-invasive; Patient friendly Shanghai Jiao Tong University Disadvantages of the aerosol • Expensive • Cooling effect • Patient coordination Shanghai Jiao Tong University Metered dose inhaler • Propellants • Product concentrate • Container • Valve