Mother nature's gifts to diseases of man All Approved Drugs 01JAN81-30JUN06 (N-1 S*/NM 40% 10% 146 ND 39% 309% Figure 1. derived compound in Phase Il or Phase IlI clinical trials or undergoing drug registration.Due to space limitations.only NP or NP-derived compounds in Phase IlI clinical trials or undergoing drug registration are described for oncology (Section 4).The clinical status of each compound is correct to the end of October 2006.For those people interested in an in-depth listing of NP-derived compounds in clinical trials in all therapeutic areas should consult the reviews by Butler [10]and Kinghorn and co-workers [11].Also worth reading are the two reviews on the role of NPs in drug discovery today [12,13]and Sneader's book on the history of drug discovery [14]. 2 Anti-infectives (antibacterials,antifungals and antiparasitics) 2.1 Antibacterials The advent of the antibacterial era is often reckoned to be from the discov- ery of penicillin by Fleming in 1928(and reported in the British Medical Literature in 1929),though there were anecdotal reports of earlier work- ers(Tyndall,Roberts and Pasteur in the 1870s)recognizing antagonism 5Mother nature’s gifts to diseases of man 5 derived compound in Phase II or Phase III clinical trials or undergoing drug registration. Due to space limitations, only NP or NP-derived compounds in Phase III clinical trials or undergoing drug registration are described for oncology (Section 4). The clinical status of each compound is correct to the end of October 2006. For those people interested in an in-depth listing of NP-derived compounds in clinical trials in all therapeutic areas should consult the reviews by Butler [10] and Kinghorn and co-workers [11]. Also worth reading are the two reviews on the role of NPs in drug discovery today [12, 13] and Sneader’s book on the history of drug discovery [14]. 2 Anti-infectives (antibacterials, antifungals and antiparasitics) 2.1 Antibacterials The advent of the antibacterial era is often reckoned to be from the discov￾ery of penicillin by Fleming in 1928 (and reported in the British Medical Literature in 1929), though there were anecdotal reports of earlier work￾ers (Tyndall, Roberts and Pasteur in the 1870s) recognizing antagonism Figure 1. Drugs approved against all diseases by the FDA or their equivalents in other countries from the 1 January 1981 to 30 June 2006