Antibodies bind to epitopes displayed on the o surface Ab(BCR)binds the B-cell epitope directly, of antigens TCR binds with a self-MHC-T-cell-epitope complex The epitopes recognized The antigen must first The epitope peptide binds The T-cell receptor binds to by T-cell receptors are be broken down into to a self molecule, an a complex of MHC molecule often buried peptide fragments MHC molecule and epitope peptide TCR epitope peptide molecule MHC moleculeAb (BCR) binds the B-cell epitope directly, TCR binds with a self-MHC-T-cell-epitope complex