What is the structure of the folded state? The side chain packing problem. Given the coordinates of the backbone and the sequence of the protein put the side chains on in their correct conformation This is a sub-problem of protein structure prediction Note Also useful for final model refinement in homology modeling How should we search side chain conformational space?What is the structure of the folded state? The side chain packing problem. Given the coordinates of the backbone, and the sequence of the protein, put the side chains on in their correct conformation. This is a sub-problem of protein structure prediction. Note: Also useful for final model refinement in homology modeling. How should we search side chain conformational space?