CHAPTER 20 CARBoXYLIC ACID DERIVATIVES: NUCLEOPHILIO ACYL SUBSTITUTION his chapter differs from preceding ones in that it deals with several related classes of compounds rather than just one. Included are 1. Acyl chlorides, RCCI 2. Carboxylic acid anhydrides, RCOCR 3. Esters of carboxvlic acids rcor 4. Carboxamides, RCNH,. RCNHR and RCNR,2 These classes of compounds are classified as carboxylic acid derivatives. All may converted to carboxylic acids by hydrolysis RCX+H2O—RCOH+ HX Carboxylic acid Water Carboxylic Conjugate acid derivative of leaving group Back Forward Main MenuToc Study Guide ToC Student o MHHE WebsiteCHAPTER 20 CARBOXYLIC ACID DERIVATIVES: NUCLEOPHILIC ACYL SUBSTITUTION This chapter differs from preceding ones in that it deals with several related classes of compounds rather than just one. Included are 1. Acyl chlorides, 2. Carboxylic acid anhydrides, 3. Esters of carboxylic acids, 4. Carboxamides, , , and These classes of compounds are classified as carboxylic acid derivatives. All may be converted to carboxylic acids by hydrolysis. RCX O X Carboxylic acid derivative H2O Water HX Conjugate acid of leaving group Carboxylic acid RCOH O X RCNR 2 O X RCNHR O X RCNH2 O X RCOR O X RCOCR O X O X RCCl O X 774 Back Forward Main Menu TOC Study Guide TOC Student OLC MHHE Website