Regulatory strategies .Product accumulates (The enzymatic rate"slows down"as product accumulates and equilibrium is approached); .Substrates and cofactors(The availability of substrates and cofactors will determine the enzymatic reaction rate); .Allosteric control (aspartate transcarbamoylase, hemoglobin); Multiple forms of enzymes (lactate dehydrogenase); Reversible covalent modification (e.g. phosphorylation/dephosphorylation,protein kinase A); Regulatory strategies •Product accumulates (The enzymatic rate “slows down” as product accumulates and equilibrium is approached); •Substrates and cofactors (The availability of substrates and cofactors will determine the enzymatic reaction rate); •Allosteric control (aspartate transcarbamoylase, hemoglobin); • Multiple forms of enzymes (lactate dehydrogenase); • Reversible covalent modification (e.g. phosphorylation/dephosphorylation, protein kinase A);