Brief Contents PART I QUESTIONS Introducing Developmental Biology 1 CHAPTER 1 Developmental Anatomy 5 CHAPTER 2 Developmental Genetics 31 CHAPTER 3 Cell-Cell Communication in Development 69 PART II SPECIFICATION Introducing Cell Commitment and Early Embryonic Development 109 CHAPTER 4 Fertilization 121 CHAPTEr 5 Early Development in Selected Invertebrates 159 CHAPTER 6 The Genetics of Axis Specification in Drosophila 203 CHAPTER 7 Amphibians and Fish 247 ChaPTer8 Birds and Mammals 287 PART III THE STEM CELL CONCEPT Introducing Organogenesis 323 CHAPTER9 The Emergence of the Ectoderm 333 CHAPTER 10 Neural Crest Cells and Axonal Specificity 373 CHAPTER 11 Paraxial and Intermediate Mesoderm 413 CHAPTER 12 Lateral Plate Mesoderm and the Endoderm 445 CHAPTER 13 Development of the Tetrapod Limb 485 CHAPTER 14 Sex Determination 511 CHAPTER 15 Postembryonic Development 541 CHAPTER 16 The Saga of the germ Line 583 PART IV SYSTEMS BIOLOGY Expanding Developmental Biology to Medicine, Ecology, and Evolution 617 CHAPTER 17 Medical Aspects of Developmental Biology 625 CHAPTER 18 Developmental Plasticity and Symbiosis 659 CHAPTER 19 Developmental Mechanisms of Evolutionary Change 683Brief Contents PART I QUESTIONS Introducing Developmental Biology 1 CHAPTER 1 Developmental Anatomy 5 CHAPTER 2 Developmental Genetics 31 CHAPTER 3 Cell-Cell Communication in Development 69 PART II SPECIFICATION Introducing Cell Commitment and Early Embryonic Development 109 CHAPTER 4 Fertilization 121 CHAPTER 5 Early Development in Selected Invertebrates 159 CHAPTER 6 The Genetics of Axis Specification in Drosophila 203 CHAPTER 7 Amphibians and Fish 241 CHAPTER 8 Birds and Mammals 287 PART III THE STEM CELL CONCEPT Introducing Organogenesis 323 CHAPTER 9 The Emergence of the Ectoderm 333 CHAPTER 10 Neural Crest Cells and Axonal Specificity 373 CHAPTER 11 Paraxial and Intermediate Mesoderm 413 CHAPTER 12 Lateral Plate Mesoderm and the Endoderm 445 CHAPTER 13 Development of the Tetrapod Limb 485 CHAPTER 14 Sex Determination^ 511 CHAPTER 15 Postembryonic Development 541 CHAPTER 16 The Saga of the Germ Line 583 PART IV SYSTEMS BIOLOGY Expanding Developmental Biology to Medicine, Ecology and Evolution 617 CHAPTER 17 Medical Aspects of Developmental Biology 625 CHAPTER 18 Developmental Plasticity and Symbiosis 659 CHAPTER 19 Developmental Mechanisms of Evolutionary Change 683