TRA NEW ENGLAND IOURNAL E MEDICINE ORIGINAL ARTICLE Clinical Characteristics of Coronavirus Disease 2019 in China C.Lei,D.S.C.Hui S.Li,Jin-lin Wang.Z.Liang.Y.Pens YLuYa-hua Hu.P.Per an吗 lian-mi Wang, .Liu.Z.Chen.G.Li.Z.Zheng,S.Qiu,J.Luo,C.Ye,S.Zhu and N.Zhong,for the China Medical Treatment Expert Group for Covid-19* ABSTRACT BACKGROUND Since December 2019,when coronavirus disease 2019(Covid-19)emerged in Wuhan characterist METHODS ted da 53eracted China thr gh January 29.2020.The pri 151Y ang Rd ma to an intensive care unit (CU).the use of mechanical ventilation.or death. DESIITE A时 The median age of the patients was 47 years;419%of the patients were female The primary composite end point occurred in 67 patients (6.1%),including 5.0% who we ere ac mitte d to the ICU,2.3%who underwent invasive mecl hanical ventila ildli who die ally to th 2120 Th ere fever (43 go on admission and gg zo du ing ho NEJM.org. (678%)Diarrhea was uncommon (38%)The median incubation period was 4 dav (interquartile range,2 to 7).On admission,ground-glass opacity was the most O:10.1055/NE]Mo 2002037 common radiologic finding on chest computed tomography(CT)(56.4%).No radic disoser isese Lyphocytopenia was with nonsever frst2 months of the current outbreak,Covid-19 spread rapidly throughout China and caused varying deg es of illness.Patients often without fever,and many did not have abnormal radiologic findings.(Funded by the National Health Commission of China and others.) N ENGLJ MED NEJM.ORG The New England Journal of Medicing Dow loaded from nejm.M s Me All rights The new england journal o f medicine n engl j med nejm.org 1 The authors’ full names, academic de￾grees, and affiliations are listed in the Appendix. Address reprint requests to Dr. Zhong at the State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Rd., Guangzhou, Guangdong, China, or at nanshan@vip.163.com. *A list of investigators in the China Medi￾cal Treatment Expert Group for Covid-19 study is provided in the Supplementary Appendix, available at NEJM.org. Drs. Guan, Ni, Yu Hu, W. Liang, Ou, He, L. Liu, Shan, Lei, Hui, Du, L. Li, Zeng, and Yuen contributed equally to this article. This article was published on February 28, 2020, and updated on March 3, 2020, at NEJM.org. DOI: 10.1056/NEJMoa2002032 Copyright © 2020 Massachusetts Medical Society. BACKGROUND Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients. METHODS We extracted data regarding 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces, autonomous regions, and municipalities in mainland China through January 29, 2020. The primary composite end point was admission to an intensive care unit (ICU), the use of mechanical ventilation, or death. RESULTS The median age of the patients was 47 years; 41.9% of the patients were female. The primary composite end point occurred in 67 patients (6.1%), including 5.0% who were admitted to the ICU, 2.3% who underwent invasive mechanical ventila￾tion, and 1.4% who died. Only 1.9% of the patients had a history of direct contact with wildlife. Among nonresidents of Wuhan, 72.3% had contact with residents of Wuhan, including 31.3% who had visited the city. The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). Diarrhea was uncommon (3.8%). The median incubation period was 4 days (interquartile range, 2 to 7). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (CT) (56.4%). No radio￾graphic or CT abnormality was found in 157 of 877 patients (17.9%) with nonsevere disease and in 5 of 173 patients (2.9%) with severe disease. Lymphocytopenia was present in 83.2% of the patients on admission. CONCLUSIONS During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness. Patients often presented without fever, and many did not have abnormal radiologic findings. (Funded by the National Health Commission of China and others.) ABSTRACT Clinical Characteristics of Coronavirus Disease 2019 in China W. Guan, Z. Ni, Yu Hu, W. Liang, C. Ou, J. He, L. Liu, H. Shan, C. Lei, D.S.C. Hui, B. Du, L. Li, G. Zeng, K.-Y. Yuen, R. Chen, C. Tang, T. Wang, P. Chen, J. Xiang, S. Li, Jin-lin Wang, Z. Liang, Y. Peng, L. Wei, Y. Liu, Ya-hua Hu, P. Peng, Jian-ming Wang, J. Liu, Z. Chen, G. Li, Z. Zheng, S. Qiu, J. Luo, C. Ye, S. Zhu, and N. Zhong, for the China Medical Treatment Expert Group for Covid-19* Original Article The New England Journal of Medicine Downloaded from nejm.org at SOUTHERN MEDICAL UNIVERSITY on March 6, 2020. For personal use only. No other uses without permission. Copyright © 2020 Massachusetts Medical Society. All rights reserved