Article Cell Gut Microbiota Orchestrates Energy Homeostasis during Cold Graphical Abstract Authors Claire Chevalier, Ozren Stojanovic, Didier J. Colin,., Nicola Zamboni, Siegfried Hapfelmeier, Mirko Trajkovski Uptake Correspondence mirko trajkovski@unige. ch Insulin sensitivity I eMicrobiota Increased gut In brief Thermogenesis Cold exposure markedly shifts the composition of the gut microbiota. This “ cold microbiota” mediates remodeling of the fat and intestinal tissues, helping the host to withstand periods of high energy demand White o.e Microbiota arm Highlights Accession Numbers Cold exposure leads to marked changes in the gut GsE74228 microbiota composition Cold microbiota transplantation increases insulin sensitivity and WAT browning e Cold exposure or cold transplantation increase the gut size and absorptive capacity Reconstitution of cold-suppressed A. muciniphila reverts the increased caloric uptake etal,2015,cell163,13601374 rossMark December 3. 2015 @2015 Elsevier Inc. http://dx.doi.org/10.1016/j.cell.2015.11.004 Ce empressArticle Gut Microbiota Orchestrates Energy Homeostasis during Cold Graphical Abstract Highlights d Cold exposure leads to marked changes in the gut microbiota composition d Cold microbiota transplantation increases insulin sensitivity and WAT browning d Cold exposure or cold transplantation increase the gut size and absorptive capacity d Reconstitution of cold-suppressed A. muciniphila reverts the increased caloric uptake Authors Claire Chevalier, Ozren Stojanovic, Didier ! J. Colin, ..., Nicola Zamboni, Siegfried Hapfelmeier, Mirko Trajkovski Correspondence mirko.trajkovski@unige.ch In Brief Cold exposure markedly shifts the composition of the gut microbiota. This ‘‘cold microbiota’’ mediates remodeling of the fat and intestinal tissues, helping the host to withstand periods of high energy demand. Accession Numbers GSE74228 Chevalier et al., 2015, Cell 163, 1360–1374 December 3, 2015 ª2015 Elsevier Inc. http://dx.doi.org/10.1016/j.cell.2015.11.004