Progress Manifestation Pulse is slow, heart murnures cardiomegaly, hypothermia, hypotonia enlarged tongue, skin cold and dry, umbilical hernia, hair is dry Mental retardation growth stuntedProgress Manifestation • Pulse is slow, heart murnures, cardiomegaly,hypothermia, hypotonia, enlarged tongue, skin cold and dry, umbilical hernia, hair is dry • Mental retardation • growth stunted