REAL Classification ●B- cell neoplasms I Precursor B-cell neoplasm: precursor B-lymphoblastic leukemia/lymphoma l Peripheral B-cell neoplasms A B-cell chronic lymphocytic leukemialprolymphocytic leukemia/small lymphocyticlymphoma B Lymphoplasmacytoid lymphoma/immunocytoma C Mantle cell lymphoma D. Follicle center cell lymphoma, follicular 1. Provisional cytologic grades: small cell l mixed small and large cell ll large cell 2. Provisional subtype: diffuse, predominantly small cell typeREAL Classification ⚫ B-cell neoplasms I. Precursor B-cell neoplasm: precursor B-lymphoblastic leukemia/lymphoma II. Peripheral B-cell neoplasms A. B-cell chronic lymphocytic leukemia/prolymphocytic leukemia/small lymphocyticlymphoma B. Lymphoplasmacytoid lymphoma/immunocytoma C. Mantle cell lymphoma D. Follicle center cell lymphoma,follicular 1. Provisional cytologic grades: I small cell, II mixed small and large cell, III large cell 2. Provisional subtype: diffuse, predominantly small cell type