Etiology of jaundice secondary to unconjugated hyperbilirubemia Overproduction of bilirubin a Increased rate of hemolysis Patient with a positive Coombs test ◆ Rh incompatibility ABO blood group incompatibility Patient with negative Coombs test Abnormal red cell shapes Red cell enzyme abnormalities G-6-PD Patient with bacterial or viral sepsis a Nonhemolytic causes of increased biliurbin load e Extravascular hemorrhage ◆ Polycythemia(红细胞增多症) ◆ Exaggerated enterohepatic circulation(肠肝循环) of biliurbinEtiology of jaundice secondary to unconjugated hyperbilirubemia Overproduction of bilirubin ◼ Increased rate of hemolysis ◆ Patient with a positive Coombs test ⧫ Rh incompatibility ⧫ ABO blood group incompatibility ◆ Patient with negative Coombs test ⧫ Abnormal red cell shapes ⧫ Red cell enzyme abnormalities G-6-PD ◆ Patient with bacterial or viral sepsis ◼ Nonhemolytic causes of increased biliurbin load ◆ Extravascular hemorrhage ◆ Polycythemia (红细胞增多症） ◆ Exaggerated enterohepatic circulation（肠肝循环）of biliurbin