Balance between the deposit and clearance of ic determines the situation of the diseases Persistence of antigen Clearance dysfunction of mesangial cells disability of mononuclear macrophage component or function defect of complements IC deposit clearanceBalance between the deposit and clearance of IC determines the situation of the diseases • Persistence of antigen • Clearance dysfunction of mesangial cells • disability of mononuclear macrophage • component or function defect of complements IC deposit > clearance