HC 6.An isosteric series of compounds shown below,where X=CH2, NH,O,S,was synthesized.The order of potency was X=NH>O> S>CH2.How can you rationalize these results (you need to consider the three-dimensional structure)? CH: H 7.Tyramine binds to a receptor that triggers the release of norepinephrine,which can raise the blood pressure.If the tyramine receptor were isolated,and you wanted to design a new antihypertensive agent,discuss what you would do in terms of lead discovery and modification. HO -NH2S Cl CH3 H3C 6. An isosteric series of compounds shown below, where X = CH2, NH, O, S, was synthesized. The order of potency was X= NH > O > S > CH2 . How can you rationalize these results (you need to consider the three-dimensional structure)? X CH3 H 7. Tyramine binds to a receptor that triggers the release of norepinephrine, which can raise the blood pressure. If the tyramine receptor were isolated, and you wanted to design a new antihypertensive agent, discuss what you would do in terms of lead discovery and modification. HO NH2