Main properties of clonal Selection(Burnet, 1978) x Elimination of self antigens x Proliferation and differentiation on contact of mature lymphocytes w ith antigen x Restriction of one pattern to one differentiated cell and retention of that pattern by clonal descendants x Generation of new random genetic changes subsequently expressed as diverse antibody patterns a form of accelerated somatic mutationMain Properties of Clonal Selection (Burnet, 1978) Elimination of self antigens Proliferation and differentiation on contact of mature lymphocytes with antigen Restriction of one pattern to one differentiated cell and retention of that pattern by clonal descendants; Generation of new random genetic changes, subsequently expressed as diverse antibody patterns by a form of accelerated somatic mutation