BEH.462/3. 962J Molecular Principles of Biomaterials Spring 2003 Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering Today Applications of hydrogels in bioengineering Covalent hydrogels Physical hydrogels Synthesis of hydrogel biomaterials Synthesis of hydrogel biomaterials Physical gels Formation Aq son-==zs Associating hydrophobic groups synthesis in organic solvent readily assembled in situ Synthesis of pluronics? Anionic polymerization? Formation of ionic gels: coacervates, nanoparticles LCST polymer gelation 1- △T Associating hydrophobic group Thermodynamics of LCST Lecture 7-Hydrogels 1 1 of 2BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering Today: Applications of hydrogels in bioengineering Covalent hydrogels Physical hydrogels Synthesis of hydrogel biomaterials Synthesis of hydrogel biomaterials Physical gels Formation: Aq soln Associating hydrophobic groups synthesis in organic solvent readily assembled in situ Synthesis of pluronics? Anionic polymerization? Formation of ionic gels: coacervates, nanoparticles LCST polymer gelation: ∆T Associating hydrophobic groups Thermodynamics of LCST Lecture 7 – Hydrogels 1 1 of 2