1.(CH3CH2)2Al--CN 2. H3O 1.(CH3cH22 Addition of Alky l and Aryl Groups: Alkyl, aryl and vinyl groups can be added to conjugated ketones using the appropriate dialky lcopperlithium reagent 1. (CH3)cUlI 2.H3O 1.(H2C=CH)2CuLi The utility of conjugate addition reactions in organic synthesis is demonstrated by the reaction sequence shown below 1.(CBHs) CuL H CH3C-P(CsHs) Carbony l a-Substitution Reactions Carbonyl compounds exist in equilibrium with a very small amount of a structural isomer, termed an enol.An enol is formed by abstraction of a proton from the a-carbon, delocalization of the electrons onto the carbonyl oxygen, and finally, protonation of the oxygen to give an alkene bonded to an alcohol(an enol!). It is important to note that this is a true equilibrium and the carbonyl compound and its enol are distinct different chemicalAddition of Alkyl and Aryl Groups: Alkyl, aryl and vinyl groups can be added to conjugated ketones using the appropriate dialkylcopperlithium reagent. The utility of conjugate addition reactions in organic synthesis is demonstrated by the reaction sequence shown below: Carbonyl -Substitution Reactions Carbonyl compounds exist in equilibrium with a very small amount of a structural isomer, termed an enol. An enol is formed by abstraction of a proton from the −carbon, delocalization of the electrons onto the carbonyl oxygen, and finally, protonation of the oxygen to give an alkene bonded to an alcohol (an enol!). It is important to note that this is a true equilibrium and the carbonyl compound and its enol are distinct different chemical