STRESSACTIVATED PATHWAYS Humoral pathway STRESS RAS pathway () Limbic system Visceral brain Norepinephrine Endocrine Neuronal pathway Hypothalmus CRF 41 residues Renin Fight or flight Anterior pituitary ACTH 39 residues Angiotensin i& Adrenal cortex Adrenal cortex cortisol glycogen Aldosterone GR receptor increased Antiinflammatory effects blood+- Sodium uptake cell death pressureSTRESS ACTIVATED PATHWAYS Humoral pathway STRESS Neuronal pathway RAS pathway Limbic system Visceral brain Endocrine Hypothalmus Anterior pituitary Adrenal cortex cortisol (-) (-) (-) CRF 41 residues ACTH 39 residues GR receptor Antiinflammatory effects cell death glycogen Fight or flight Norepinephrine Renin Angiotensin I & II Adrenal cortex Aldosterone Sodium uptake increased blood pressure