Pathophysiology病理生理 1. Sensitization致敏 contact Antigens 一 Respiratory mucosa呼吸道粘膜 activate CD4+ T Lymphocyte Th2 cell secrete Deliver signal IL4,L-5,IL-6,-10,-13( Mediators炎症介质) ↓ activate B cell Hemaendotheliocyte血管内皮细胞 ICAM-1( intercellular adhesion molecule1胞间粘附分子-1) produce attach Eosinophil嗜酸细胞 IgE Mast cell肥大细胞 go to nasal mucosa receptor on basophil嗜碱细胞 T lymphocyte淋巴细胞Pathophysiology病理生理 1.Sensitization 致敏 contact Antigens Respiratory mucosa 呼吸道粘膜 activate CD4+ T Lymphocyte Th2 cell secrete Deliver signal IL-4,IL-5,IL-6,IL-10,IL-13 (Mediators炎症介质) activate B cell Hemaendotheliocyte 血管内皮细胞 ICAM-1(intercellular adhesion molecule-1细胞间粘附分子-1) produce attach Eosinophil嗜酸细胞 IgE Mast cell 肥大细胞 go to nasal mucosa receptor on basophil嗜碱细胞 T lymphocyte淋巴细胞