BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 QQ-00 Fig. I A Assembly model for alpha-toxin in lipi bilayers. water. sion in the membrane plane to form pre-pore complexes (c) C Lecithin liposomes carrying reincorporate (Bhakdi 1996) Targeting to antigen presenting cells that cross-prime o Mechanism not yet known Figure 2. Pn Example Approach: ' release from endosomes Pat Stayton and Allan Hoffman U. Washington Murthy et al. encrypted polymers o concept: mask membrane-disruptive moieties on a drug-carrying polymer until endosomes are reached Lecture 16-intracellular delivery 5 of 8BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 (Bhakdi 1996) x Targeting to antigen presenting cells that cross-prime8,9 o Mechanism not yet known Example Approach: ‘smart’ release from endosomes 10 ƒ Pat Stayton and Allan Hoffman U. Washington- Murthy et al. ƒ ‘encrypted’ polymers o concept: mask membrane-disruptive moieties on a drug-carrying polymer until endosomes are reached Lecture 16 – intracellular delivery 5 of 8