·976· 智能系统学报 第15卷 ×10 6 2 234567891011121314151617181920212223242526272829303132333435 样本编号 (e)No.2374 图2区分DS、HS和NC样本集的脂质 Fig.2 The lipids which can distinguish the DS,HS and NC samples. 病人数多、病因复杂，并且复发率高，虽然部分患 onibacterium acnes phylotypes and acne severity:an obser- 者在青春期之后，其症状会有所缓解，但是对于 vational prospective study[J].Journal of the European 大部分患者来说，座疮症状会持续很长时间，对 academy of dermatology and venereology,2017,31(9): 患者的生活质量造成很大的影响，因此对于痤疮 e398-e399 的研究和治疗是一个具有重要意义的课题。本文 [5]王鸿.寻常型痤疮发病机制研究进展).西南医科大学 从宏基因组学的角度分析引起痤疮发病的脂质， 学报，2018,41(4)：385-388. 并尝试使用MCCA方法分析DS、HS和NC3个样 WANG Hong.Research progress on the pathogenesis of 本集，可以得到仅对某一样本集有显著影响的脂 acne vulgaris[J].Journal of Southwest Medical University, 2018,41(4):385-388 质，以及同时有效区分3个样本集的脂质。实验 [6]FITZ-GIBBON S,TOMIDA S,CHIU B H,et al.Propioni- 结果显示，MCCA方法分析获得的脂质可以有效 bacterium acnes strain populations in the human skin mi- 的区分3种不同的皮肤状态，并且对痤疮的预 crobiome associated with acne[J].Journal of investigative 防、诊断和治疗有一定的辅助指导意义。在痤疮 dermatology,2013,133(9):2152-2160. 发病过程中，也许存在某种脂质的数值虽然很 [7]DAGNELIE M.CORVEC S,SAINT-JEAN M,et al.461 小，但却对痤疮有一定影响，而本文使用MCCA Diversity of Propionibacterium acnes phylotypes accord- 方法获取脂质对样本集的贡献时，会一定程度上 ing to body localization in acne patients versus healthy 弱化对这些脂质的分析，对于这些脂质还需要进 controls[J].Journal of investigative dermatology,2017, 一步的研究。 137(10,Suppl2):S271. [8]ZOUBOULIS CC,JOURDAN E,PICARDO M.Acne is 参考文献 an inflammatory disease and alterations of sebum composi- [1]MARONI G,ERMIDORO M,PREVIDI F,et al.Auto- tion initiate acne lesions[J].Journal of the European mated detection,extraction and counting of acne lesions academy of dermatology and venereology,2014,28(5): for automatic evaluation and tracking of acne severity[Cl// 527-532. Proceedings of 2017 IEEE Symposium Series on Computa- [9]吴贊，吉杰，张玲琳，等.微生物在痤疮发病中的作用) tional Intelligence.Honolulu,USA,2017:1-6. 中国皮肤性病学杂志，2016,30(3)：311-314 [2]LUCUT S,SMITH M R.Dermatological tracking of WU Yun,JI Jie,ZHANG Linglin,et al.Roles of microor- chronic acne treatment effectiveness[C]//Proceedings of ganisms in the pathogenesis of acne[J].The Chinese journ- 2016 38th Annual International Conference of the IEEE al of dermatovenereology,2016,30(3):311-314. Engineering in Medicine and Biology Society.Orlando, [10]ZHANG Xuegong,LIU Shansong,CUI Hongfei,et al. USA.2016:5421-5426. Reading the underlying information from massive meta- [3]THIBOUTOT D M,DReNO B,ABANMI A,et al.Practic- genomic sequencing data[J].Proceedings of the IEEE al management of acne for clinicians:an international con- 2017,105(3):459-473. sensus from the global alliance to improve outcomes in [11]VAN OPSTAL E J,BORDENSTEIN S R.Rethinking acne[J].Journal of the American academy of dermatology, heritability of the microbiome[J].Science,2015, 2018,78(2,Suppl1:S1-S23.el. 3496253:1172-1173. [4]PAUGAM C.CORVEC S,SAINT-JEAN M,et al.Propi- [12]KANG D W,PARK J G,ILHAN Z E,et al.Reduced in-病人数多、病因复杂，并且复发率高，虽然部分患 者在青春期之后，其症状会有所缓解，但是对于 大部分患者来说，痤疮症状会持续很长时间，对 患者的生活质量造成很大的影响，因此对于痤疮 的研究和治疗是一个具有重要意义的课题。本文 从宏基因组学的角度分析引起痤疮发病的脂质， 并尝试使用 MCCA 方法分析 DS、HS 和 NC3 个样 本集，可以得到仅对某一样本集有显著影响的脂 质，以及同时有效区分 3 个样本集的脂质。实验 结果显示，MCCA 方法分析获得的脂质可以有效 的区分 3 种不同的皮肤状态，并且对痤疮的预 防、诊断和治疗有一定的辅助指导意义。在痤疮 发病过程中，也许存在某种脂质的数值虽然很 小，但却对痤疮有一定影响，而本文使用 MCCA 方法获取脂质对样本集的贡献时，会一定程度上 弱化对这些脂质的分析，对于这些脂质还需要进 一步的研究。 参考文献： MARONI G, ERMIDORO M, PREVIDI F, et al. Auto￾mated detection, extraction and counting of acne lesions for automatic evaluation and tracking of acne severity[C]// Proceedings of 2017 IEEE Symposium Series on Computa￾tional Intelligence. Honolulu, USA, 2017: 1−6. [1] LUCUT S, SMITH M R. Dermatological tracking of chronic acne treatment effectiveness[C]//Proceedings of 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Orlando, USA, 2016: 5421−5426. [2] THIBOUTOT D M, DRéNO B, ABANMI A, et al. Practic￾al management of acne for clinicians: an international con￾sensus from the global alliance to improve outcomes in acne[J]. Journal of the American academy of dermatology, 2018, 78(2, Suppl 1): S1–S23.e1. [3] [4] PAUGAM C, CORVEC S, SAINT-JEAN M, et al. Propi￾onibacterium acnes phylotypes and acne severity: an obser￾vational prospective study[J]. Journal of the European academy of dermatology and venereology, 2017, 31(9): e398–e399. 王鸿. 寻常型痤疮发病机制研究进展 [J]. 西南医科大学 学报, 2018, 41(4): 385–388. WANG Hong. Research progress on the pathogenesis of acne vulgaris[J]. Journal of Southwest Medical University, 2018, 41(4): 385–388. [5] FITZ-GIBBON S, TOMIDA S, CHIU B H, et al. Propioni￾bacterium acnes strain populations in the human skin mi￾crobiome associated with acne[J]. Journal of investigative dermatology, 2013, 133(9): 2152–2160. [6] DAGNELIE M, CORVEC S, SAINT-JEAN M, et al. 461 Diversity of Propionibacterium acnes phylotypes accord￾ing to body localization in acne patients versus healthy controls[J]. Journal of investigative dermatology, 2017, 137(10, Suppl 2): S271. [7] ZOUBOULIS C C, JOURDAN E, PICARDO M. Acne is an inflammatory disease and alterations of sebum composi￾tion initiate acne lesions[J]. Journal of the European academy of dermatology and venereology, 2014, 28(5): 527–532. [8] 吴贇, 吉杰, 张玲琳, 等. 微生物在痤疮发病中的作用 [J]. 中国皮肤性病学杂志, 2016, 30(3): 311–314. WU Yun, JI Jie, ZHANG Linglin, et al. Roles of microor￾ganisms in the pathogenesis of acne[J]. The Chinese journ￾al of dermatovenereology, 2016, 30(3): 311–314. [9] ZHANG Xuegong, LIU Shansong, CUI Hongfei, et al. Reading the underlying information from massive meta￾genomic sequencing data[J]. Proceedings of the IEEE, 2017, 105(3): 459–473. [10] VAN OPSTAL E J, BORDENSTEIN S R. Rethinking heritability of the microbiome[J]. Science, 2015, 349(6253): 1172–1173. [11] [12] KANG D W, PARK J G, ILHAN Z E, et al. Reduced in￾DS HS NC 样本编号 (e) No.2374 × 104 6 7 5 4 2 3 1 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 含量值/(m·z−1 ) 图 2 区分 DS、HS 和 NC 样本集的脂质 Fig. 2 The lipids which can distinguish the DS, HS and NC samples. ·976· 智 能 系 统 学 报 第 15 卷