安徽医科大学国际教育学院教案与讲稿 Teaching Plan for International Students,AHMU Title of the course:Clinical Pharmacogenetics Chapter:13 Teacher's name: Qiong Huang Grade:2013 Department:Clinical Medicine,School of International Education Time:14:30-16:50 Date(D/M/Y):3/16/2016 1.Recognize the concept of clinical pharmacogenetics,the purpose of clinical Teaching pharmacogenetics 2.Recognize the definition of single nucleotide polymorphisms and its Objectives; Teaching significance Requirements 3.Recognize the effects of CYP enzyme polymorphisms on drug metabolism 4.Master the ethnic differences and individual differences in clinical pharmacogenetics 1.Introduction to clinical pharmacogenetics 2.The purpose of clinical pharmacogenetics Teaching 3.The definition of single nucleotide polymorphisms and its significances Content 4.CYP enzymes phenotypes and effects 5.Case Report Teaching Teaching Focus:CYP enzymes phenotypes and effects. Focus; Difficult Problems:the concept and content of clinical pharmacogenetics, and how to use it in clinical practice Difficult Problems Solutions:Give examples of clinical drug use (the metabolic enzyme,the polymorphism and the effects)and the mechanisms of drug metabolism,the and their regulated dosage,and discuss about the rational drug therapy in patients Solutions according to its genotypes. Introduction to clinical pharmacogenetics 5min Time The purpose of clinical pharmacogenetics 5min Allotment SNPs and its significances 5min CYP phenotypes and effect 20min Pharmacogenetic principles and discuss 5min 1.The purpose of pharmacogenetics or pharmacogenomics Assignment 2.Single nucleotide polymorphism 3.Give an example to explain CYP2D6 genetic polymorphism and drug concentrations. 1.Principle of Clinical Pharmacology(Second Edition);Arthur J.Atkinson 2.Basic Clinical Pharmacology;Bertram G.Katzung Reference 3.Pharmacogenetics:from molecular to clinical;Zhou HongHao Text 4.Zhou,HH.Koshakji,RP.Silberstein,DJ.Wilkinson,GR.Wood,AJ Altered sensitivity to and clearance of propranolol in men of Chinese descent as compared with American whites.N Engl J Med 1989;320,565-570.安徽医科大学国际教育学院教案与讲稿 1 Teaching Plan for International Students, AHMU Title of the course: Clinical Pharmacogenetics Chapter: 13 Teacher’s name: Qiong Huang Grade: 2013 Department: Clinical Medicine, School of International Education Time: 14:30—16:50 Date (D/M/Y): 3/16/2016 Teaching Objectives; Teaching Requirements 1. Recognize the concept of clinical pharmacogenetics, the purpose of clinical pharmacogenetics 2. Recognize the definition of single nucleotide polymorphisms and its significance 3. Recognize the effects of CYP enzyme polymorphisms on drug metabolism 4. Master the ethnic differences and individual differences in clinical pharmacogenetics Teaching Content 1. Introduction to clinical pharmacogenetics 2. The purpose of clinical pharmacogenetics 3. The definition of single nucleotide polymorphisms and its significances 4. CYP enzymes phenotypes and effects 5. Case Report Teaching Focus; Difficult Problems and their Solutions Teaching Focus: CYP enzymes phenotypes and effects. Difficult Problems: the concept and content of clinical pharmacogenetics, and how to use it in clinical practice Solutions: Give examples of clinical drug use (the metabolic enzyme, the polymorphism and the effects) and the mechanisms of drug metabolism, the regulated dosage, and discuss about the rational drug therapy in patients according to its genotypes. Time Allotment Introduction to clinical pharmacogenetics 5min The purpose of clinical pharmacogenetics 5min SNPs and its significances 5min CYP phenotypes and effect 20min Pharmacogenetic principles and discuss 5min Assignment 1. The purpose of pharmacogenetics or pharmacogenomics 2. Single nucleotide polymorphism 3. Give an example to explain CYP2D6 genetic polymorphism and drug concentrations. Reference Text 1. Principle of Clinical Pharmacology (Second Edition); Arthur J. Atkinson 2. Basic & Clinical Pharmacology; Bertram G. Katzung 3. Pharmacogenetics: from molecular to clinical; Zhou HongHao 4. Zhou, HH. Koshakji, RP. Silberstein, DJ. Wilkinson, GR. Wood, AJ. Altered sensitivity to and clearance of propranolol in men of Chinese descent as compared with American whites. N Engl J Med 1989; 320,565-570