Medical Genetics AFP is made in the fetal liver, and some escapes into the maternal circulation It is widely used as a screening test for a DS fetus, msafp and at least 1 other screening test are recommended for all pregnancies not having amniocentesis by the american College of obstetrics, and the American College of Medical GeneticsMedical Genetics AFP is made in the fetal liver, and some escapes into the maternal circulation. It is widely used as a screening test for a DS fetus. MSAFP and at least 1 other screening test are recommended for all pregnancies not having amniocentesis by the American College of Obstetrics, and the American College of Medical Genetics