ORGANIC CHEMISTRY Chapter 15 o When designing a synthesis of substituted benzenes, the order in which the substituents are introduced is crucial o Example: Synthesize ortho, meta-, and para-nitrobenzoic acid from toluene NO HNO HSO Fe nO2 nO2 Department of Chemistry, Xiamen UniversityORGANIC CHEMISTRY Department of Chemistry, Xiamen University Chapter 15 When designing a synthesis of substituted benzenes, the order in which the substituents are introduced is crucial Example: Synthesize ortho-, meta-, and para-nitrobenzoic acid from toluene Cl NO2 NO2 Cl NO2 HNO3 H2SO4 Cl2 Fe