1. Translation(protein synthesis) necessitates the coordinated interplay of about 300 macromolecules in the cells The most complex of all biosynthetic path ways 60 to 90 macromolecules for making up the protein synthesizing machine ribosomes Over 20 enzymes for activating the amino acids Over 10 auxiliary proteins for the initiation, elongation and termination of the polypeptide chains Account for up to 90% of the chemical energy used by a cell for all biosynthetic reactions1. Translation (protein synthesis) necessitates the coordinated interplay of about 300 macromolecules in the cells • The most complex of all biosynthetic pathways. • 60 to 90 macromolecules for making up the protein￾synthesizing machine ribosomes • Over 20 enzymes for activating the amino acids. • Over 10 auxiliary proteins for the initiation, elongation and termination of the polypeptide chains. • Account for up to 90% of the chemical energy used by a cell for all biosynthetic reactions