Xeroderma Pigmentosum Cause Nucleotide excision repair(NEr)enzymes are mutated NER-DNA repair mechanism Reduction or elimination of ner Unrepaired damage can lead to mutations, changing the information of the DNA in the individual If mutation affect the important genes this can lead to serious disease For example: p53, tumor suppressor genes, this order can lead to cancerIf mutation affect the important genes, this can lead to serious disease For example: p53, tumor suppressor genes, this order can lead to cancer Reduction or elimination of NER Unrepaired damage can lead to mutations, changing the information of the DNA in the individual Nucleotide excision repair (NER) enzymes are mutated NER - DNA repair mechanism Xeroderma Pigmentosum Cause