COOCH3 CHx Mg/THF CH2MgX Fluoconazole OH (1 ChOlI C(CH2 CI) (2)(CICH2)CO (u Mg, THF CH,,-NSynthesis N N N CH2X Mg/THF N N N CH2MgX F F COOCH3 N N N CH2 C O F F Fluoconazole F F Br (1 ) C4H9Li (2) (ClCH2)2CO F F C(CH2Cl)2 OH N N NH (1 ) Mg, THF (2) N N N CH2 C O CH2 N N N