Medical Genetics Skewed heteroplasmy mtDNA mutation surpasses pathogenic threshold in 1 tissue Examples: A3243G may produce only cardiomyopathy Myopathy with early respiratory involvementMedical Genetics Skewed heteroplasmy – mtDNA mutation surpasses pathogenic threshold in 1 tissue – Examples: A3243G may produce only cardiomyopathy; Myopathy with early respiratory involvement