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n(=oru omplish c ArCH2CH3 CH-CH-CO2H (Ar=aryl group) Ar 1.Br2,light 2.NaCN 3.H0,? B) 1.Br2,light 2.Mg,ether 3C0、 4.H0 c) 1.Br2,light 2.KOH 3.03 3.H202,f D) 1.Br2,light 2.CH;CO2K 3.H-O" R上Soth andB Page6 Page 6 12. Several 2-arylpropanoic acids are used as analgesics (painkillers). Three of these [Ibuprofen (= Advil), Naproxen (= Aleve) and Ketoprofen (= Orudis KT)] are currently available in over-the-counter form. Which of the following sets of reagents would accomplish conversion of an ethyl aromatic to a 2-arylpropanoic acid? CH3 CH CO2H Ar ArCH2CH3 ? (Ar = aryl group) A) 1. Br2, light 2. NaCN 3. H3O+ , ? B) 1. Br2, light 2. Mg, ether 3. CO2 4. H3O+ C) 1. Br2, light 2. KOH 3. O3 3. H2O2, H+ D) 1. Br2, light 2. CH3CO2 - K+ 3. H3O+ E) both A and B Ans: E
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