CBG CBG s Action mode of glucocorticoid drugs GR S(HSP70 CBG: corticosteroid binding HSP70 GR globulin (HSP90) HSP90) S: glucocorticoid steroids nucleus GR: glucocorticoid receptor Transcription GRGR HSP: heat shock protein GREGRE「■口 IP: immunophilin gene GRE: glucocorticoid- mRNA response element cytoplasm protein Altered cellular function