JOINT TISSUES Limitations to Healing Absence of a fibrin clot Absent or low vascularity Dissolution of clot in synovial fluid Cell migration restricted by matrix ° Low cell density Low mitotic activit Mechanical loading disrupts reparative tissueJOINT TISSUES JOINT TISSUES Limitations to Healing Limitations to Healing • Absence of a fibrin clot Absence of a fibrin clot –Absent or low vascularity Absent or low vascularity –Dissolution of clot in synovial Dissolution of clot in synovial fluid • Cell migration restricted by matrix Cell migration restricted by matrix • Low cell density Low cell density • Low mitotic activity Low mitotic activity • Mechanical loading disrupts Mechanical loading disrupts reparative tissue reparative tissue