Pathway for Studying Complex Disease Is the disease familial? Familial aggregation studies Yes No What causes the familial aggregation? Twin studies Adoption studies Shared environment Shared genes Path analysis Segregation analysis What types of genetic effects? Single major genes Multiple genes poradic inkage analysis Association studies Where is the gene? TDT revised from shaw 2001 ASP 复旦大学流行病学教研室付朝伟复旦大学流行病学教研室 付朝伟 14 Pathway for Studying Complex Disease Single major genes Multiple genes Sporadic Yes No Where is the gene? Linkage analysis Association studies TDT ASP -revised from Shaw, 2001 Segregation analysis What types of genetic effects? Shared environment Shared genes Twin studies Adoption studies Path analysis What causes the familial aggregation? Is the disease familial? Familial aggregation studies