1. Definition of hepatic failure →--1--1-÷----1-1------4 Various harmful factors parenchymal cells and Kupffer cells damadged severely and extensively severe disturbance of liver function in metabolism, secretion, synthesis, detoxication and immunity jaundice, bleeding, infection, renal dysfunction and encephalopathy Hepatic insufficiency (late stage)Hepatic failure hepatorenal syndrome and hepatic encephalopathy3 1. Definition of hepatic failure Various harmful factors ↓ parenchymal cells and Kupffer cells damadged severely and extensively ↓ severe disturbance of liver function in metabolism, secretion, synthesis, detoxication and immunity ↓ jaundice, bleeding, infection, renal dysfunction and encephalopathy ↓ “Hepatic insufficiency” ↓ (late stage) “Hepatic failure” hepatorenal syndrome and hepatic encephalopathy