上浒文通大学 Immune response 后 Shanghai Jiao Tong University The cell-mediated arm of the immune response involves the ingestion and digestion of antigen by antigen-presenting cells such as macrophages. Activated TH cells secrete IL-2,which causes proliferation and activation of cytotoxic T lymphocytes, and TH1 and TH2 cell subsets.TH1 cells also produce IFN-y and TNF-B,which can directly activate macrophages and NK cells. The humoral response is triggered when B lymphocytes bind antigen via their surface immunoglobulin.They are then induced by TH2-derived IL-4 and IL-5 to proliferate and differentiate into memory cells and antibody-secreting plasma cells.Regulatory cytokines such as IFN-y and IL-10 down-regulate TH2 and TH1 responses,respectively.Shanghai Jiao Tong University The cell-mediated arm of the immune response involves the ingestion and digestion of antigen by antigen-presenting cells such as macrophages. Activated TH cells secrete IL-2, which causes proliferation and activation of cytotoxic T lymphocytes, and TH1 and TH2 cell subsets. TH1 cells also produce IFN-γ and TNF-β, which can directly activate macrophages and NK cells. The humoral response is triggered when B lymphocytes bind antigen via their surface immunoglobulin. They are then induced by TH2-derived IL-4 and IL-5 to proliferate and differentiate into memory cells and antibody-secreting plasma cells. Regulatory cytokines such as IFN- γ and IL-10 down-regulate TH2 and TH1 responses, respectively. Immune response