Mechanisms of antiepilepsy drugs 1. Balance neurotransmitters(平衡递质) (1)Enhance GABAergic transmission(Cl, k+) 2)Diminish glutamate function(Ca2+, nat 2. Stabilize membrane(膜稳定作用 (1)Decrease activity of voltage-dependent Nat channels 2 Decrease activity of voltage-dependent Ca+ channels N-type(neuronal); L-type(long lasting) T-type(transient)10 Mechanisms of antiepilepsy drugs (1) Decrease activity of voltage-dependent Na+ channels (2) Decrease activity of voltage-dependent Ca2+ channels N-type (neuronal); L-type (long lasting) T-type (transient) 1. Balance neurotransmitters(平衡递质) (1) Enhance GABAergic transmission (Cl -,K+) (2) Diminish glutamate function (Ca2+ , Na+) 2. Stabilize membrane(膜稳定作用)