Ischemic atrophy A decrease in blood supply (ischemia)to a tissue as a result of arterial disease result in atrophy of the tissue due to progressive cell loses. Atrophy of the brain. A B Ischemic atrophy A B  A decrease in blood supply (ischemia) to a tissue as a result of arterial disease result in atrophy of the tissue due to progressive cell loses.  Atrophy of the brain