Assembly/Maturation/Release Processes poorly understood Prevention of assembly HIV protease inhibitors-see later Prevention of release: Relenza and Tamiflu-neuraminidase inhibitors(active against influenza viruses) prevent release of budded virus from the cell drugs target the enzyme active site-a very conserved region Both influenza a and b are blocked Need to be taken very early in course of infection No effect on non-influenza neuraminidases (different substrate specificity Tamiflu effective as a prophylactic agent