ACE inhibitors Ang-ll receptor antagonists: Angiotensinogen Kininogen Renin Kallikrein Angiotensin-l Bradykinin ACE 个Prostaglandin (kininase-ll) synthesis John Vane Angiotensin-lI Inactive products Vasoconstriction Aldosterone Vasodilation secretion ↓PVR ↑PVR ↑Na+and H2(0 retension ↓BP ↑BP ACE angiotensin-converting enzyme Ervin ErdosAngiotensinogen Angiotensin-I Angiotensin-II Vasoconstriction Aldosterone secretion  PVR  Na+ and H2O retension  BP Bradykinin Kininogen Renin Kallikrein ACE (kininase-II) Inactive products  Prostaglandin synthesis Vasodilation  PVR  BP ACE inhibitors & Ang-II receptor antagonists: ACE = angiotensin-converting enzyme John Vane Ervin Erdös