Introduction Historical Perspective Unique contribution of epidemiology to the repertoire of clinical research designs First case-control study performed in late 1950s Doll and hills study of lung cancer and smoking behavior among physicians a Jerome Cornfields classic description of Retrospective Studies New statistical tools were developed to analyze the study design -logistic regressionn Unique contribution of epidemiology to the repertoire of clinical research designs n First case-control study performed in late 1950s n Doll and Hill’s study of lung cancer and smoking behavior among physicians n Jerome Cornfield’s classic description of “Retrospective Studies” n New statistical tools were developed to analyze the study design - logistic regression Historical Perspective Introduction