o Concept of internal environment (1870) By Claude bernard ( 1813-1878) milieu interne mi: Ija: into: n French Concept of homeostasis (1920) By w. B Cannon(1871-1945) e Importance of maintaining the homeostasis k Enough nutritional substances & o2 k Low level of metabolic products co2 k Water, electrolyte, acid-base balance k Temperature, osmotic pressure, etc. o Homeostasis is a dynamic equilibrium o Regulation of homeostasis k Involve all systems, especially the lung kidney• Concept of internal environment (’1870) By Claude Bernard (1813-1878) milieu interne [`mi:lj: `int:n] [French] • Concept of homeostasis (’1920) By W. B. Cannon (1871-1945) • Importance of maintaining the homeostasis * Enough nutritional substances & O2 * Low level of metabolic products & CO2 * Water, electrolyte, acid-base balance * Temperature, osmotic pressure, etc. • Homeostasis is a dynamic equilibrium • Regulation of homeostasis * Involve all systems, especially the lung & kidney