Diagnosis and Prevention Immunoblotting assay(Western blot Treat tissue with proteinase k to digest PrPC, and then analyze with Western blot for the presence of PrPsc Immunohistochemstry: Also treat with proteinase K first Genetic analysis: For inherited mutations in the PrP gene Prevention: quarantine of animals and complete disinfection of medical devices no treatmentDiagnosis and Prevention • Immunoblotting assay (Western blot): Treat tissue with proteinase K to digest PrPC, and then analyze with Western blot for the presence of PrPSc • Immunohistochemstry: Also treat with proteinase K first • Genetic analysis: For inherited mutations in the PrP gene. • Prevention: quarantine of animals and complete disinfection of medical devices. No treatment