Pathogenesis Immunologically mediated, multisystem disease that follows an episode of group A streptococcal pharyngitis after an interval of a few weeks Type ll hypersensitivity reaction (molecular mimicry)Pathogenesis ◼ Immunologically mediated, multisystem disease that follows an episode of group A streptococcal pharyngitis after an interval of a few weeks ◼ Type II hypersensitivity reaction (molecular mimicry)