Complement Classical pathway A suitable Ab bound to Ag, Ag-Ab complex C1, c4, c2 and c3, ca++ and matt cations 1 C1 activation 2. C4 and C2 activation(generation of C3 convertase) 3. C3 activation(generation of C5 convertase) 4 Generation of c5 convertase marks the end of the classical pathwayClassical pathway A suitable Ab bound to Ag, Ag-Ab complex C1, C4, C2 and C3, Ca++ and Mg++ cations 1. C1 activation 2. C4 and C2 activation (generation of C3 convertase) 3. C3 activation (generation of C5 convertase) 4. Generation of C5 convertase marks the end of the classical pathway Complement